Comparative antibody responses and protection in mice immunised by oral or parenteral routes with influenza virus subunit antigens in aqueous form or incorporated into ISCOMs
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چکیده
منابع مشابه
Protective Immunity in Mice Following Immunization with the Cochleate-Based Subunit Influenza Vaccines
High morbidity and mortality of influenza virus infection makes it an important disease world-wide. Mouse is a very well-studied animal model for this disease with similar manifestation to human disease. It would be desirable to induce mucosal as well as circulating immune responses to obtain protection from infection and to decrease the spread of the virus. Cell mediated immunity (proliferativ...
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15 صفحه اولPCEP enhances IgA mucosal immune responses in mice following different immunization routes with influenza virus antigens
BACKGROUND We previously demonstrated that polyphosphazenes, particularly PCEP, enhance immune responses in mice immunized subcutaneously and intranasally. The objective of the present study was to investigate the efficacy of polyphosphazenes as adjuvants when delivered through different routes of vaccine administration. METHODS BALB/c mice were immunized through intranasal, subcutaneous, ora...
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Different toxoplasma antigens were entrapped within liposomes and evaluated, in this form, for their ability to protect Swiss mice against toxoplasma infection: soluble tachyzoite antigen (L/TAg), tissue cyst (L/CAg), tachyzoite plus tissue cyst (L/TCAg) or purified antigen of tachyzoite (L/pTAg). The protein used in L/pTAg was purified from tachyzoites using a stage-specific monoclonal antibod...
متن کاملIgG subclass response and protection against challenge following immunisation of mice with various influenza A vaccines.
The serum total IgG and IgG subclass and nasal wash IgA and IgG antibody responses of mice to influenza virus A/Hong Kong/68 (H3N2) subunit preparations administered parenterally as a single dose, incorporated either in immune stimulatory compounds (ISCOMs) or liposomes with Freund's Complete Adjuvant, or as an aqueous material, as well as to live, infectious virus were measured by ELISA at 10 ...
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ژورنال
عنوان ژورنال: Journal of Medical Microbiology
سال: 1995
ISSN: 0022-2615,1473-5644
DOI: 10.1099/00222615-42-1-53